As an infectious disease specialist, Dr. Gregory House is a brilliant diagnostician who loves the challenges of the medical puzzles he must solve in order to save lives. House solves the inexplicable cases that other doctors cannot understand.House isn't alone in this quest. His team includes neurologist Dr. Eric Foreman, a neurologist with a troubled youth and a desire to avoid becoming as abrasive as House; immunologist Dr. Allison Cameron - who sometimes cares too much and has conflicting feelings about House; and Dr. Robert Chase, a specialist in intensive care who has lived a very privileged life. House's good (and possibly only) friend Dr. James Wilson is an oncology specialist, who has to help and stand up for House on a regular basis, while trying to get him to face a few harsh truths.
House must also deal with his boss, Lisa Cuddy who, while often opposing House's unconventional methods, must admit that he is the best doctor on her staff. When a patient’s life hangs in the balance, House will do anything, including breaking the law, taking risks other doctors would not take, and sometimes even going as far as actually interacting with a patient. House’s methods may be controversial but his results speak for themselves.
Inconsistencies with his team forced House to hire a new batch of doctors. This year House used and elimination process and the end resulted in hiring, Dr. Lawrence Kutner, Dr. Remy Hadley, and Dr. Christopher Taub. Although his old team no longer takes orders from House they're still around to throw in their professional knowledge when need is dire. Together they will continue to solve cases most Doctors can't. Ep.23: Acceptance
An inmate on death row starts seeing hallucinations of the people he has murdered. Cuddy reluctantly offers a very excited House the case. Without a respirator the inmate will die within an hour. Stacy pulls some strings and the inmate is brought to the hospital, where House's team of doctors couldn't care less about treating a man who will die anyway. Meanwhile, Cameron is having trouble telling a patient that she has cancer and will soon die.
Ep.24: Autopsy
A young girl who suffers from cancer is about to administer her medicine when she begins hallucinating. An ill House shows up to work and Wilson asks him for help on the case. The doctors learn that the hallucinations are unrelated to the patient's cancer. After numerous tests, the doctors can find nothing wrong with the young girl. However, House believes that the girl's bravery is a symptom of a dangerous disease.
Ep.25: Humpty Dumpty
Cuddy's young handyman, Alfredo, ends up falling from her roof and she soon joins the team in figuring out what caused him to fall in the first place. Cuddy is racked with guilt, even more so after House must amputate his hand after it becomes infected, because he is the sole provider for his family. After taking a trip to his neighborhood, the team may figure out just what caused Alfredo's illness in the first place.
Ep.26: TB or Not TB
After Dr. Sebastian Charles, who is renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to the hospital after collapsing, he immediately determines all the symptoms are from TB. House does not believe it and orders rounds of tests. Soon after the case gets the attention of the media, Dr. Charles refuses any more tests and medication in order to bring to light about the medical needs in Africa. Cameron actually sees eye to eye with Dr. Charles, but House ends up making his situation worse. Meanwhile, Foreman fills in for House in the clinic with mixed results.
Ep.27: Daddy's Boy
A recent Princeton graduate ends up in internal shock while attending a frat party. With his father by his side, it's clear that Carnell is not being too truthful about his life. House soon thinks that his symptoms could be caused by a recent Spring Break trip the young man took. Meanwhile, House is actually having his own issues with his father and keeps trying to get out of a dinner engagement with both his parents who have just arrived for a visit.
Ep.28: Spin
After a professional bicyclist is brought in, House refuses to treat him because he is convinced the man is lying about using steroids to help him perform better. Cameron is upset at the fact that the man is actually a hero to little kids and ponders what she should ethically do. Meanwhile, House decides to ruin Stacy and Mark’s relationship by attending a group therapy session with Mark.
Ep.29: Hunting
A scuffle with House lands a gay man with AIDS in the hospital, where he provides the disagreeable diagnostician with a medical puzzle. The man coughs up blood on Cameron, who begins behaving uncharacteristically. Elsewhere, House finds an unusual way to spend time with Stacy.
Ep.30: The Mistake
Chase misdiagnoses a woman with an ulcer, and flashbacks dissect the case as her condition deteriorates. Stacy questions him and House about it following the patient's death and prior to a hospital disciplinary hearing.
Ep.31: Deception
After a gambler collapses in front of House while they’re both betting on horse races, the team soon discovers she’s been seeing a number of doctors for a variety of supposed illnesses. This leads everyone, but a skeptical House, to believe that it is Munchausen’s which is a disease that causes people to fake symptoms for the medical attention. Of course, with Foreman as House's supervisor, it becomes more difficult for him to get things done his way.
Ep.32: Failure to Communicate
After journalist collapses at his editor's retirement party and hits his head, he regains consciousness but his words do not make sense. Since House is in Baltimore trying to defend his Medicaid billings with Stacy, the only way the team can help figure out what's wrong with Fletcher is through the telephone conversations. Meanwhile, as they are stranded at the airport together, House and Stacy realize that they still have feelings for one another.
Ep.33: Need to Know
A young housewife, who happens to be taking some fertility medication, is brought to the hospital when she begins having muscle spasms so bad that she crashes her car. As Margo's symptoms continue to get worse, House and the team think she might have Huntington's Disease but when Margo descends into paranoia, they dig deeper and discover that she might not be telling them the whole truth. Meanwhile, after House and Stacy return from Baltimore with a rekindled relationship, Wilson begins to worry that House is just setting himself up for a hard fall. Also, Cameron is refusing to find out the results of her HIV test.
Ep.34: Distractions
A young man comes into the hospital severely burned, but the test quickly show that their is something unusual about his blood tests. The team has to get creative to figure out how to test the patient before his body completely shuts down. To make matters worse, House is hellbent on proving that one of his old medical school colleague's new migraine drug does not work no matter what he happens to be saying. So, House decides to make himself the guinea pig for his own batch of tests with some painful results.
Ep.35: Skin Deep
House must treat a teenage supermodel for her heroin addiction, but soon realizes there is something different about her. Wilson is wondering if House's increased leg pain means that his leg nerves are actually regenerating. Also, a male patient in the clinic is somehow experiencing his wife's pregnancy, including her labor pains.
Ep.36: Sex Kills
After man experiences a seizure but has no idea he has had it arrives at the hospital, House eagerly takes on the case. The team believes he has a bacterial infection, but Henry suffers a heart attack before the treatment for his infection is able to work and now needs a heart transplant. He chooses to approach the husband of the deceased woman, and feigns interest, only because he wants the heart. House and the team have to race against time to find out what the woman died of before they can use her heart for Henry.
Ep.37: Clueless
Bob comes in suffering from a breathing attack after role-playing with his wife. After trying to find out what's wrong with him, House decides to tell the man he has a sexually transmitted disease, which causes his wife to tell House a secret. Meanwhile, Wilson has moved in with House and things are not going too well for either of them.
Ep.38: Safe
Melinda, a rebellious girl, has a severe allergic reaction and ends up going into shock because she is immunocompromised from a heart transplant she had earlier in life. Soon Melinda's condition worsens and she becomes paralyzed, with the paralysis slowly moves up her legs. To make matters worse, her overprotective mother and boyfriend are constantly fighting about her condition. The team must find a way to stop the paralysis and figure out what is wrong with her before it gets to her heart. Meanwhile, House and Wilson are still having problems with their living arrangement.
Ep.39: All In
A 6 year boy is brought into the hospital with symptoms that House is convinced he has seen before in an elderly woman who died. House tries to convince Wilson to keep Cuddy from knowing what he is up to as he becomes frustrated in trying to find a way to cure the boy.
Ep.40: Sleeping Dogs Lie
After a patient, Hannah, is brought after taking an overdose of sleeping pills, it is revealed that she previously had not slept in 10 days. As her condition becomes worse, House discovers that she will need a liver transplant. It turns out that the woman's girlfriend, Max, is the perfect match. However, after the team discovers something else about the couple's relationship, it forces them in an ethical quandary. Meanwhile, Cameron accuses Foreman of stealing a medical article she wrote, but he says he wrote one almost exactly like it before hers was even submitted.
Ep.41: House vs. God
House takes the case of a Boyd, a 15 year old faith healer, who thinks he can talk to God. House thinks he's making it up, until he sees Boyd touch one of Wilson's cancer patients and she later goes into remission. After Boyd decides that he will not have brain surgery because he his afraid he will lose communication with God, the entire team must confront their feelings about faith. Meanwhile, Cameron and Foreman are still at odds over the medical article she accused him of stealing.
Ep.42: Euphoria (1)
After a police officer is shot and begins experiencing unexplained giddiness, House sends Dr. Foreman to the man's office to see if he can gather a clue as to why he is acting the way he is. Soon the officer's health begins to decline and Foreman suddenly begins to experience the exact same symptoms as the officer. The team must race against time and solve the man's case before Foreman begins to suffer the exact same fate.
Ep.43: Euphoria (2)
In the conclusion, the police officer has died and Foreman's symptoms continue to get worse. He is now experiencing the same blindness, excruciating pain and muscle contractions that the officer had just before he succumbed to the still unknown disease. As Foreman realizes that he may die, he gets in contact with his father who quickly comes to be at his side. Foreman's condition quickly begins to worsen and the only solution is a brain biopsy. House is determined to find the solution in the dead officer's apartment before Cameron has to do the biopsy on Foreman's brain.
Ep.44: Forever
After a young mother has a seizure while bathing her child and almost drowns him, House and the team must discover what is causing Kara's seizures and find a way to save her son's life. Soon, both of their conditions worsen and Kara's husband is forced to make a tough decision, but he soon learns a shocking secret about his wife. Meanwhile, Chase decides he needs a break from the hospital and House wants to know why Cuddy has asked Wilson out on a date.
Ep.45: Who's Your Daddy
House's ex-bandmate brings in a 16 year old girl Katrina victim, whom he recently just found out was his daughter, because she has been suffering hallucinations about the catastrophe. House is convinced the girl is trying to scam his friend and must work through the girl's lies to try and figure out what is truly wrong with her. Meanwhile, House is asked by Cuddy to review two medical files and discovers she is looking for a sperm donor.
Ep.46: No Reason
Just as House and his team are working on the a man with a giant, swollen tongue, a disgruntled former patient Jack Moriarty walks into House's office and shoots him. House decides he must continue to treat Vince from his ICU hospital bed with Moriarty, shot by hospital security and hand-cuffed to his bed, as his roommate. Soon, the aftereffects of the shooting begin to impact House and he starts to question his own ability to properly diagnose. As Vince's body deteriorates, House must struggle through his self-doubt and trust his team to find a way to solve the case.
